Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas.
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منابع مشابه
Physiology of IgD. IV. Enhancement of antibody production in mice bearing IgD-secreting plasmacytomas
Immune responses to trinitrophenylated hemocyanin (TNP-KLH), Ficoll (TNP-Ficoll), and Brucella abortus (TNP-BA) were examined in BALB/c mice bearing subcutaneous transplants of TEPC-1017 and TEPC-1033, the two known IgD-secreting BALB/c plasmacytomas. Both primary and secondary 19S and 7S splenic plaque-forming cell (PFC) responses in spleen to intravenously injected TNP-KLH were enhanced three...
متن کاملPHYSIOLOGY OF IgD
Classic studies by Rowe et al . (1) in the human and by Vitetta and coworkers (2) in the mouse have established that IgD is a major membrane immunoglobulin . This has led to a variety of studies and speculation regarding its biological function . Based upon the effect of anti-IgD on the in vitro primary response, Cambier et al . (3) suggested that the presence of IgD on the cell surface was cri...
متن کاملEnhancement of antibody responses by IgD-binding factors induced by anti-IgD treatment of spleen cells.
Treatment of normal BALB/c splenocytes with anti-mouse IgD antibodies at 0 degrees C followed by incubation of the cells at 37 degrees C resulted in the formation of soluble factors that selectively inhibit rosette formation of lymphocytes bearing Fc delta receptors with IgD-coated erythrocytes (i.e., IgD-binding factors). Treatment of the same cells with anti-IgM antibodies failed to induce th...
متن کاملPhysiology of IgD. I. Compensatory phenomena in B lymphocyte activation in mice treated with anti-IgD antibodies
The role of delta-positive cells in the immune response was studied by comparing the effects of treatment with allotype-specific IgD hybridoma antibody on homozygous BALB/c or SJL/J and heterozygous (BALB x SJL)F1 mice. Homozygous mice, injected from birth with the relevant anti-delta antibody, made primary or secondary immune responses to intravenously injected trinitrophenyl (TNP)-Brucella ab...
متن کاملMeningeal infiltration by non-myelomatous IgD-secreting plasma cell dyscrasias.
Two cases of meningeal invasion by non-myelomatous plasma cell dyscrasias--a plasma cell leukaemia and an extramedullary plasmacytoma--are described. Both were secretors of IgD paraprotein and both were diagnosed in life, characteristics which we have not found in any other published case of plasma cell leptomeningitis. Analysis of our patients and of another 25 cases suggests as predisposing f...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1984
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.159.1.103